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SMSMSE and SEP Compatibility

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Can anyone tell me whether Symantec Endpoint Protection 12.1.6 is supposed to be compatible with Symantec Mail Security for Microsoft Exchange 6.5.2?  We're running Exchange 2010 where one of the admins upgraded one of our mail servers from SEP 11 to 12 after which a handful of SAVFMS* processes started constantly using more CPU than normal.  They also re-entered the same list of exclusions which was in SEP 11 but high CPU usage persists.  Are there perhaps additional exclusions for Exchange that are required for SEP 12?

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