Outlook won’t connect to Exchange 365

Of all my users I have one system whose Outlook 2013 will not connect to the Exchange 365 (i.e. outlook.office365.com). It will display “trying to connect” and finally “disconnected”. If I then go in and disable SEP, BAM it connects and works.

I’ve tried both a Office Repair and Symantec Endpoint Protection repair. I tried adding an Exceptions \ Security Risk Exception \ Web Domain \ Outlook.Office365.com.

Has anyone seen this or have ideas?

Enviroment

Office / Outlook 2013

SEP 12.1.6

Exchange online 365 (i.e. Outlook.Office365.com)